这种鼻喷剂可以通过绕过血脑屏障来治疗侵袭性脑癌。

胶质母细胞瘤仍然是脑癌中最致命且最难以捉摸的形式之一，主要是因为血脑屏障将肿瘤与常规治疗隔离开来。

为了克服这一问题，研究人员开发了一种开创性的鼻腔治疗方法，该方法将免疫激活疗法直接输送到大脑。通过沿着鼻腔中的神经传播，这些药用滴剂进入中枢神经系统，而无需进行侵入性手术。这种直接途径使药物能够绕过传统的生物屏障，确保强效抗癌剂到达最需要它们的大脑组织。

该疗法通过触发一种通常用于对抗病毒威胁的强大免疫途径起作用，现在被重新用于从内部攻击肿瘤细胞。科学家们利用先进的纳米技术将遗传物质封装到稳定的纳米颗粒核心中，保护药物免于降解。在最近的研究中，这种方法不仅在小鼠中激活了免疫防御并减缓了肿瘤生长，而且与其他免疫增强药物结合使用时，还提供了更持久的保护。虽然仍需进一步的临床试验，但这种非侵入性策略为对抗耐药性脑癌的斗争开辟了充满希望的新领域。

来源：Zhou, Y., 等。鼻内递送cGAMP负载纳米颗粒在胶质母细胞瘤中触发STING介导的抗肿瘤免疫力。《美国国家科学院院刊》。

This nasal spray can treat aggressive brain cancer by bypassing the blood-brain barrier.

Glioblastoma remains one of the most lethal and elusive forms of brain cancer, largely because the blood-brain barrier shields tumors from conventional treatments.

To overcome this, researchers have developed a pioneering nasal treatment that delivers immune-activating therapy directly to the brain. By traveling along the nerves in the nasal cavity, these medicinal drops enter the central nervous system without the need for invasive surgery. This direct route allows the medication to bypass traditional biological barriers, ensuring that potent cancer-fighting agents reach the brain tissue where they are needed most.

The therapy works by triggering a powerful immune pathway typically reserved for fighting viral threats, now repurposed to attack tumor cells from within. Scientists utilized advanced nanotechnology to package genetic material into stable nanoparticle cores, protecting the drug from degradation. In recent studies, this approach not only activated immune defenses and slowed tumor growth in mice but also provided longer-lasting protection when combined with other immune-boosting drugs. While further clinical trials are necessary, this non-invasive strategy offers a promising new frontier in the fight against treatment-resistant brain cancers.

source: Zhou, Y., et al. Intranasal delivery of cGAMP-loaded nanoparticles triggers STING-mediated antitumor immunity in glioblastoma. Proceedings of the National Academy of Sciences.

是的，根据一项真实研究，这是真的。WashU Medicine 和 Northwestern 的研究人员在《美国国家科学院院刊》（PNAS，2025）上发表了关于鼻内“纳米滴剂”的研究——这些是带有 DNA 片段的球形核酸，能够激活 STING 免疫途径。在胶质母细胞瘤小鼠模型中，它们通过鼻神经到达大脑，减缓了肿瘤生长，并提高了生存率，而无需手术或系统性副作用。前景可期，但仍处于临床前阶段——人体试验即将展开。

Yes, it's true based on a real study. Researchers at WashU Medicine and Northwestern published in PNAS (2025) on intranasal "nanodrops"—spherical nucleic acids with DNA snippets that activate the STING immune pathway. In mice with glioblastoma, they reached the brain via nasal nerves, slowed tumors, and boosted survival without surgery or systemic side effects. Promising, but preclinical—human trials ahead.